Driving directions to Lancaster, PA 393 mi ? about 7 hours 21 mins Via I-95 N, I-95 N, I-95 N, I-295 N, Crain Hwy/US-301, Crain Hwy/US-301 - remove all Suggested routes Chapel Hill, N Carolina 1. Head south on E Franklin St toward N Estes Dr/NC-1750 135 ft 2. Make a U-turn at N Estes Dr/NC-1750 1.1 mi 3. Slight left at N Fordham Blvd/US-15/US-501 Continue to follow US-15/US-501 3.3 mi 4. Merge onto US-15 N/US-501 N via the ramp to Durham/I-85 4.5 mi 5. Take the exit onto I-85 N Entering Virginia 128 mi 6. Take the exit onto I-95 N toward Richmond 9.7 mi 7. Take exit 61A for VA-10 toward Hopewell 0.4 mi 8. Turn right at W Hundred Rd/VA-10 3.9 mi 9. Merge onto I-295 N via the ramp to Washington 26.0 mi 10. Take exit 41A to merge onto Chamberlayne Rd/US-301/VA-2 toward Hanover Continue to follow US-301/VA-2 29.5 mi 11. Turn right at Richmond Turnpike/US-301 0.2 mi 12. Turn left to stay on Richmond Turnpike/US-301 Continue to follow US-301 Partial toll road Entering Maryland 79.8 mi 13. Continue on Crain Hwy/MD-3 (signs for MD-3/Crofton) 9.6 mi 14. Merge onto I-97 N via the ramp on the left to MD-3/Baltimore 9.4 mi 15. Take exit 17A to merge onto I-695 W toward Towson/Baltimore 21.7 mi 16. Slight right at I-83 N (signs for I-83) Entering Pennsylvania 41.9 mi 17. Take exit 19 for Market St/PA-462 0.3 mi 18. Slight right at N Hills Rd 0.6 mi 19. Turn right at US-30 E 20.0 mi 20. Take the Harrisburg Pike exit 0.3 mi 21. Turn right at Harrisburg Pike 1.2 mi 22. Continue on Harrisburg Ave 0.8 mi 23. Turn right at PA-272/N Prince St/US-222 0.3 mi 24. Turn left at W Chestnut St/PA-23 0.3 mi Lancaster, PA